Cialis is also known by Tadalafil and works by hampering the functioning of PDE5, which is an isoenzyme present in the arterial wall smooth muscle tissue of the penis and the lungs. The inhibition of the PDE5 cause relaxation of blood vessels, increases blood flow into the penis, and thus helps in getting good erection.
The process of erection also involves the role of parasympathetic nervous system that is responsible for the release of nitric oxide (NO) in the corpus cavernosum of the penis. This nitric oxide binds to the receptors of the enzyme guanylate cyclase leading to raised levels of cyclic guanosine monophosphate (cGMP). This improved level causes smooth muscle relaxation in the corpus cavernosum, leading to increased inflow of blood and thus finally an erection.
Cialis doesn't work without sexual stimulation, and as a result lack of activation of the Nitric Oxide/cGMP system, erection is restrained. Apart from treatment of Erectile Dysfunction, clinical trials of cialis are going on for the treatment of pulmonary hypertension. All the clinical trials are based on the PDE-5 inhibiting property. It is supposed that with the inhibition of this enzyme, cialis can help in opening up blood vessels in the lungs, reducing pulmonary arterial resistance and pressure, and thus decreasing the work pressure of the right ventricle of the heart.
Once you are sexually excited, cialis can help you attain an enhanced and lasting erection to achieve a satisfactory orgasm. No matter Erectile Dysfunction is mild, moderate or severe, Cialis has been found clinically effective in treating all of them and improving erection to experience a successful intercourse. We can point out the effectiveness of cialis in the following manner;
- Confident about erection
- Hard and enhanced erection
- Lasting erection until you get a successful climax after successful intercourse
- Complete satisfaction with sexual activity
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